Potential antiproliferative effects of tocotrienols, the major vitamin E component in palm oil, were investigated on the growth of both estrogen-responsive (ER+) MCF7 human breast cancer cells and estrogen-unresponsive (ER-) MDA-MB-231 human breast cancer cells, and effects were compared with those of alpha-tocopherol (alphaT). We based this speculation on the . To date, tocotrienols' beneficial effects have been shown clinically in ovarian and pancreatic cancer, and pre-clinically for breast, prostate, lung, colon, liver, and skin cancer. [ 3] Abstract. New Double Strength Tocotrienols ( 125mg) We have recently changed our source of Tocotrienols to an oil obtained from the Annatto plant in preference to that obtained from palm oil. Moreover, we have demonstrated that specific tocotrienols increase ER translocation into the nucleus which, in turn, activates the expression of estrogen-responsive genes ( MIC - 1, EGR - 1 and Cathepsin D) in breast cancer cells only expressing ER cells (MDA-MB-231) and in cells expressing both ER isoforms (MCF-7). They seem to be in the tropical fats, doesnt soybean oil have like 0 tocotrienols. In Part 1, we discussed the basics of this member of the vitamin E family and explained why tocotrienols have more health benefits than tocopherols. There are four reputable research centers that are currently furthering their research on the ability of palm tocotrienol complex to inhibit both the estrogen positive and negative human breast cancer cells. Delta-tocotrienol was found be the most potent inducer of apoptosis in both types of human breast cancer cells and was twice as potent as gamma-tocotrienol in inducing apoptosis. 2) The study cited on Anabolic shows raised test and free test without effecting DHT. I wonder if coconut oil also has some. 2005;29(4):383-8. Although tocotrienols . Synthetic vitamin E is primarily made up of just one of those . High-dietary alpha-tocopherol or mixed tocotrienol has no effect on bone mass, density, or turnover in male rats during skeletal maturation. I3C and DIM can improve estrogen metabolism. Both tocotrienol and tocopherol have further four subtypes that are found naturally: alpha, beta, gamma, and delta. View about # on Facebook. Help Reduce and Prevent Inflammation In almost all studies and clinical trials, Tocotrienols have been observed to have the ability to reduce inflammation, prevent several associated diseases, and chronic ailments. (Yes, I understand the relationship between test, free test, and DHT. OTHER NAME(S): Alpha-Tocotrienol, Alpha-Tocotrinol, Alpha Tocotr . I3C is known to improve the ratio of estrogen types. Show More Overview Uses Side Effects Precautions Interactions Dosing Reviews (1) Overview Vitamin Eis an essential nutrient. tocotrienols have been shown to exert additional benefits to the cardiovascular system including an ability to decrease in the amount of cholesterol plaque in arteries, lower the level of the extremely damaging lipoprotein (a), prevent the aggregation of platelets, and inhibit the expression of cellular adhesion molecules.1,10 all of these On the basis of a transcriptomic platform, we have recently demonstrated a novel mechanism for tocotrienol activity that involves estrogen receptor (ER) signaling. The term Vitamin E is utilized to describe eight molecules, subdivided into two groups, tocopherols and tocotrienols (TTs). In animal models, tocotrienols have been shown to exert antiatherogenic effects via antioxidant-dependent and -independent mechanisms. The neuroprotective activity will also be presented and discussed. International Journal of Endocrinology. Aktifanus AT, Shuid AN, Rashid NHA, Ling TH, Loong CY, Saat NM. It is estimated that worldwide over 508,000 women died in 2011 due to breast cancer. We continue our chat with Dr. Barrie Tan about the health benefits of tocotrienols. . Tocotrienols' chemical structures with shorter, unsaturated tails have greater mobility than tocopherols in cell membranes and thus protect more area from . Postmenopausal osteoporosis is a condition of decreasing bone density accompanied by high bone turn-over, and is due to estrogen deficiency that occurs with the arrival of menopause in women. The results confirmed higher serum levels of tocotrienols and lysophospholipids, but lower acylcarnitines and catabolites of tryptophan and steroids in subjects given 600mg TT. Inflammation is a curse, and Tocotrienol is the best antidote to date, against that curse. Our earlier studies have shown that tocotrienol was able to prevent and even reverse osteoporosis in oestrogen deficiency, testosterone deficiency, glucocorticoid excess, and nicotine exposure [ 7 - 13 ]. Unlike tocopherols, tocotrienols are unsaturated and possess an isoprenoid side chain. Recent studies have indicated tocotrienols (one kind of vitamin E, a potent antioxidant) supplement may be good for mitigating negative impacts of obesity in postmenopausal women. Potential antiproliferative effects of tocotrienols, the major vitamin E component in palm oil, were investigated on the growth of both estrogen-responsive (ER+) MCF7 human breast cancer cells and estrogen-unresponsive (ER-) MDA-MB-231 human breast cancer cells, and effects were compared with those of alpha-tocopherol (alphaT). Researchers have shown that tocotrienols can create new artery formation after a stroke, protect vital brain circuitry, and improve pancreatic cancer survival in laboratory studies. 2012. We treated the rats for two months with estrogen or tocotrienols. In silico simulations and in vitro binding analyses indicate a high affinity of specific forms of tocotrienols for ER, but not for ER. By cutting this abnormal blood supply, tocotrienol prevents the flow of nutrients the tumors use to fuel their growth, essentially starving them. Tocotrienols are found in annatto, palm oil, rice bran, coconut oil, and barley (Table 24.1).The tocotrienol content in reference to tocopherols is 100% in annatto, 4 and almost 70% in palm oil. Potential antiproliferative effects of tocotrienols, the major vitamin E component in palm oil, were investigated on the growth of both estrogen-responsive (ER+) MCF7 human breast cancer cells and estrogen-unresponsive (ER-) MDA-MD-231 human breast cancer cells, and effects were compared with those of -tocopherol (T). Tocotrienols have been shown to suppress the proliferation and induce apoptosis (a type of cell death) of tumor cells, including those of the breast, colon, liver, lungs, stomach, skin, pancreas and prostate. Recently, we have learned that vitamin E tocotrienols maybe a powerful weapon against breast cancer. A Canadian company, Eannatto has successfully harvested Annatto for Tocotrienols to deliver it to . alpha, beta, delta, and gamma tocopherols and alpha, beta, gamma, and delta tocotrienols. Tocotrienols can reduce or reverse inflammation and free radical damage that undermines heart health. Studies have shown that tocotrienols are effective in preventing the proliferation of both estrogen responsive (MCF7,ZR-75-1) and estrogen non . In this pilot clinical trial, which is the first of this nature, women with primary estrogen receptor--positive breast cancer were given a combination of tamoxifen and also tocotrienol capsules for 5 . Testosterone improves muscle mass and bone density and can have a positive effect on the heart brain and blood vessels while higher levels of estrogen put men at greater risk for chronic illness. Previous studies have shown the osteoprotective effects of tocotrienols on animals with estrogen-deficient bone loss (31)(32) (33) as well as those with testosterone-deficient bone loss (34)(35 . Introduction. Vitamin E also acts as an estrogen receptor antagonist, meaning that it blocks the reception of estrogen in . In order for vitamin E to be effective, you need all eight of the compounds. Vitamin E was initially discovered in 1938 as a "fertility factor". 1) The hairloss study used 100mg of Tocotrienols while the the study cited on Anabolic used almost 500mg of Tocopherols. Effects of Tocotrienol and Lovastatin Combination on Osteoblast and Osteoclast Activity in Estrogen-Deficient Osteoporosis Saif Abdul-Majeed,1 Norazlina Mohamed,1 and Ima-Nirwana Soelaiman 1 1Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia There are basically two types of breast cancer: estrogen-positive and estrogen-negative. It also has higher antioxidant activity than alpha-tocopherol. They can also deter tumor growth in certain cancers - and Alpha-tocotrienol, as well as Gamma-tocotrienol, has been shown to enhance the life of mice that are suffering . Moreover, we have demonstrated that . The other broad category of vitamin E biochemicals is tocopherols. Palm tocotrienol supplementation enhanced bone formation in oestrogen-deficient rats. Facebook gives people the power to share and makes the world more open and connected. Affecting 8 million . Tocotrienol, a member of the vitamin E family, can be found in annatto bean, palm oil and rice bran. Tocotrienol; Vitamin E; Cancer; Absorption; Natural sources. Table 2 Tocotrienol intake and risk of breast cancer-specific death/recurrence in women with early breast cancer and estrogen receptor-positive tumors receiving tamoxifen Full size table The multivariate HR for local or systemic recurrence in the TRF-plus-tamoxifen group compared with the placebo-plus-tamoxifen group was 0.84 (95% CI, 0.43 to 1 . Androgens - increases testosterone, lowers prolactin, antagonizes estrogen. Tamper Resistant: Use only if safety seal is intact. This study is intended to investigate the metabolic differences between postmenopausal women with low bone mass at baseline and after 12 weeks of supplementation. This study aimed to examine the effects of tocotrienol, a vitamin E analog, on bone loss due to estrogen deficiency. Tocotrienols may upregulate apoptosis in these lines. Palm Tocotrienol Supplementation Enhanced Bone Formation in Oestrogen-Deficient Rats. Doi:10.1155/2012/532862. They can also positively affect cholesterol levels reducing total cholesterol and decreasing LDL (low-density lipoprotein). It is shown in this study that the anti-oxidative activity of tocotrienols prevents estrogen epoxide formation and therefore may reduce the incidence of breast cancer. Vitamin E, which exhibits antioxidant properties, is a generic term that represents derivatives of tocopherol and tocotrienol (Kamal-Eldin and Appelqvist 1996).Antioxidants are generally believed to inhibit the development of cardiovascular disease and cancer by neutralizing free radical damage (Meydani 1995).Therefore, consumption of vitamin E-enriched foods may reduce the incidence of . This oxidized estrogen inhibits nuclear RNA synthesis as well. Our previous study showed that tocotrienol increased the trabecular bone volume and trabecular number in ovariectomized rats. Previous studies indicated that tocotrienols boost the breast cancer fighing effects of tamoxifen in vivo. et al. Whether you have estrogen-responsive or estrogen-non responsive breast cancer cells, Delta-tocotrienol is normally the best form of tocotrienols to induce cancer cell death. Estrogen-positive cancers are estrogen-sensitive, which means that estrogen can stimulate the tumors to grow. Importantly, tocotrienols provide health benefits beyond those of vitamin E. Both tocopherols and tocotrienols are powerful antioxidants, but tocotrienols also possess powerful neuroprotective, anti-cancer and cholesterol-lowering properties that are not shared by vitamin E in the form of alpha-tocopherol. The results of the study found that estrogen-responsive MCF7 cells were more susceptible than the estrogen-nonresponsive MDA-MB-435 cells. Tocotrienol prevented the neurotoxicity in the MPTP mouse model of PD (Nakaso et al., 2016 . Issue: Aug 2014 The Little-Known Benefits Of Tocotrienols. 2012 36. Support digestive health Tocotrienol is especially effective at fighting the effects of stress on the gastrointestinal system. Dosage. (2017, Apr 6). The neuroprotective effect of tocotrienols was understood to be mediated through estrogen receptor-. A study showed that tocotrienols are the components of vitamin E responsible for growth inhibition in human breast cancer cells in vitro as well as in vivo through estrogen-independent mechanisms. Int J Endocrinol. Although, a very promising study has been conducted on Annatto based Tocotrienol which has been proven to help you combat breast cancer and during recovery too. Tocotrienols in other words can be called "biochemicals of vitamin E family". It has also been shown to contribute to immunoregulation, antibody production, and resistance to implanted tumors. Read More. At that time, both estrogen and vitamin E were being widely studied, though the exact structure of the tocopherol molecule wasn't defined until 1936-37. Tocotrienols are members of the vitamin E family of nutrients. Tocotrienols are a form of vitamin E, having an unsaturated isoprenoid side-chain rather than the saturated side-chain of tocopherols. In a pre-clinical study conducted on estrogen-positive and -negative breast cancer cell lines, tocotrienols when administered together with the standard breast cancer drug tamoxifen, enhances the anti-cancer effects of the latter suggesting tocotrienol's potential in treating certain types of breast cancer. Annatto-derived tocotrienol was chosen for this study due Often overlooked by scientists and consumers, tocotrienols are a crucial component of the entire spectrum of vitamin E with their own unique health benefits. It has been shown that specific TTs affect the growth of several lines of tumour cells, and that this activity is not shared by tocopherols. Tocotrienols are often found in natural sources such as palm or rice brain oil. Tocotrienol exhibits bone anabolic actions that actually build bone, and reversed the harmful changes induced by menopause. However, no study has ever been done the role of tocotrienols in obesity-associated outcome measures in postmenopausal women. In this short review, tocotrienol ability to inhibit cancer cell growth and induce apoptosis thanks to specific mechanisms, not shared by tocopherols, such as the binding to Estrogen Receptor- (ER) and the triggering of endoplasmic reticulum (EndoR) stress will be described. The mechanism of this effect is unclear, but there is some speculation about it. In the same paper , addressing the molecular mechanism underlying tocotrienols' activity, we wanted to speculate about the possible presence of a putative (orphan) receptor, possibly located at the level of the cellular membrane and able to accept tocotrienols and other estrogen mimetics as selective ligands. It has recently been shown that tocotrienols are the components of vitamin E responsible for growth inhibition in human breast cancer cells in vitro as well as in vivo through estrogen-independent mechanisms. Therefore they are used in the prevention of atherosclerosis and maintaining a healthy cardiovascular system. Do you think its even from digesting palm oil or just its reaction when it touches teeth. Tocotrienol shares a similar structure with tocopherol, consisting of a chromanol head and a long carbon tail. Potential antiproliferative effects of tocotrienols, the major vitamin E component in palm oil, were investigated on the growth of both estrogen-responsive (ER+) MCF7 human breast cancer cells and estrogen-unresponsive (ER-) MDA-MD-231 human breast cancer cells, and effects were compared with those of -tocopherol (T). 6 This unique structural configuration allows tocotrienols to cross saturated fatty layers of tissue more readily, thus likely favoring . Tocotrienols possess antioxidant properties against lipid peroxidation. Europe PMC is an archive of life sciences journal literature. Estrogen is a phenolic compound that shares similarities with . Tocotrienols boost the ability of Tamoxifen to fight breast cancer and improves survival. Tocotrienol has three double bonds on the carbon tail, while tocopherol has only single bonds. These effects are likely due to the antioxidant capacity of tocotrienols. 3. Tocotrienols can also reduce the power of other cardiovascular health risk factors, including. The annatto plant has the highest concentration of delta and gamma tocotrienol commercially available, containing 90% delta and 10% gamma tocotrienol. People take tocotrienols by mouth for aging, Alzheimer's disease, clogged arteries, cancer, diabetes, a genetic disorder called familial dysautonomia, high cholesterol, kidney failure, and stroke. Tocotrienol, a member of vitamin E that exhibits antioxidant activities, has shown potential as an agent for the treatment of osteoporosis. 8, [14], [15] In silico simulations and in vitro binding analyses indicate a high affinity of specific forms of tocotrienols for ER, but not for ER. Macadamia nuts supposedly are also a rich source of tocotrienols. This encapsulated product contains no hidden coatings, excipients, binders, fillers, shellacs, artificial colors or fragrance. Gamma-tocopherol's main job is to neutralize reactive oxygen and reactive nitrogen. Since many years natural sources of foods have been studies intensively to investigate their role in prevention and treatment of many health disorders including cancer [1-5].Caner is the most lethal disease in humans with very low survival rate [6,7] because of the cancer associated mutations in cells, and . Vitamin E tocotrienols may boost bone health, with or without statins, suggests new data from a study with osteoporotic rats. It has also been shown to contribute to immunoregulation, antibody production, and resistance to implanted tumors. As vitamin E is an antioxidant, it lowers oxidative stress (caused by free radicals) and therefore impacts hormones (testosterone and DHT) levels positively, by protecting them. People apply tocotrienols to the skin for buns, hair growth, and scars. The tocotrienol-rich fraction of palm oil (TRF) consists of 23.54% -tocotrienol, 43.16% -tocotrienol, 9.83% -tocotrienol, and 23.5% -tocopherol and is extracted from palm oil post-esterification and following distillation, crystallization, and chromatography processes [ 6, 7 ]. It is the cause of any changes in your nipple/pecs (gyno), mood, libido, hardness, bloat, skin, prostate, appetite - you name it, when you feel off 90% of the time is due to low/high Estrogen levels. alpha, beta, gamma and delta. Small daily doses of delta and gamma tocotrienols isolated from annatto bean reduced serum levels of cholesterol, triglycerides, and LDL by 15-20% [41]. The tocotrienol-rich fraction (TRF) from palm oil contains -tocopherol and a mixture of -, - and -tocotrienols. Comparison of the effects of tocotrienol and estrogen on the bone markers and dynamic changes in postmenopausal osteoporosis rat model. Within 8 to 10 weeks, there was a significant reduction of 10-12% of total cholesterol level in the group that received tocotrienols. And if that wasn't enough they can slow and even repress the progression of atherosclerotic plaques [ * ]. The supplements are encapsulated so dont touch the teeth. Earlier studies have shown that tocotrienols display anticancer activity. Keywords. There are no studies that show it raises DHT. annatto tocotrienols lowered the eective dose of lovas-tatin and oered a novel approach to cancer prevention and therapy [40]. ABSTRACT: Potential antiproliferative effects of tocotrienols, the major vitamin E component in palm oil, were investigated on the growth of both estrogen-responsive (ER+) MCF7 human breast cancer cells and estrogen-unresponsive (ER) MDA-MB-231 human breast cancer cells, and effects were compared with those of -tocopherol (T). Tocotrienols have been found to inhibit the growth of several tumor cell lines in culture, including both estrogen receptor-negative and estrogen receptor-positive human breast cancer cells. Estrogen-positive cancers are estrogen-sensitive, which means that estrogen can stimulate the tumors to grow. In summary, 12-week TT supplementation altered many serum metabolite levels in postmenopausal women. Contains no dairy, wheat, yeast, gluten, corn, sugar, starch, soy, preservatives or hydrogenated oils. Tocotrienols, members of the vitamin E family, are natural compounds found in a number of vegetable oils, wheat germ, barley, and certain types of nuts and grains. . Like tocopherols, tocotrienols are also of four types viz. tocotrienols, more specifically delta and gamma isomers that are derived from annatto and palm, are an important part of vitamin e, which is now being extensively researched for its antihyperlipidemic, antidiabetic, antiinflammatory, anticancer, and immune-supportive actions.373-376 in human and animal studies, tocotrienols have been shown to When you hit your sweet spot you will know, you can't miss it. Previous studies have found that 12 weeks of tocotrienol supplementation decreased bone resorption and improved bone turnover rate in postmenopausal women with estrogen deficiency. . Sesamin is a lignan derived from sesame seeds ( Sesamum indicum) that appears to inhibit vitamin E metabolism, which causes a relative increase in circulating levels of -tocopherol and -tocotrienol; it shows most promise in augmenting the efficacy of vitamin E supplements. Oxidation of estrogen increases its capacity to induce breast cancer. Vitamin E had been found to improve fertility of both male and female animals, and to prevent intrauterine death of the embryo or fetus, so it was called the "antisterility vitamin."